As an experimental discipline, ISO 14644-1 clean technology has also practiced various research methods in its development process, and has made considerable development and progress in these years.

The following will introduce several research schemes used in the research field of ISO 14644-1:

(1) The decoupling principle is an important experimental theoretical method. Often, the decoupling principle can transform the original complex or "chaotic" physical phenomenon into a set of simple physical phenomena, which can make the experimenter more clearly. To clearly see the essence of the phenomenon, the experiment or analysis process is greatly simplified and finally solved, so the decoupling principle has become an important theoretical method for experimental scientific research and practice.

 In terms of theory, in 1978, on the basis of the traditional theory of uniform distribution of particles in the whole room in a clean room, in 1978, the researcher Xu Zhonglin of China Academy of Building Sciences first analyzed various factors that affect the uneven distribution of dust concentration in ISO 14644-1 clean room. The dust concentration distribution in the clean room is decoupled and decoupled into 3 distribution areas (i.e. the mainstream area below the air supply port, the return air area in the return air area, and the rest area is the eddy current area).

The traditional ISO 14644-1 clean space pollution control mechanism is mainly to send clean air through the high-efficiency filter arranged at the end of the air supply. Since it is difficult to avoid the leakage of the filter material, filter and installation joint surface of the filter during the production, transportation and installation process of the filter, the leakage of the high-efficiency filter is inevitable, so only relying on sealing and blocking Leakage cannot effectively solve the leakage problem. The full-covered high-efficiency filter in the one-way flow clean room not only plays the role of filtration, but also plays the role of flow equalization and leakage prevention. Integrated, greatly improving the requirements for the end filter. In this context, using the leakage barrier theory, decoupling the three functions of filtration, flow sharing and leakage prevention of the terminal high-efficiency filter has become a new technical measure for the development of clean rooms.

(2) Numerical simulation of airflow organization through computational fluid dynamics (CFD) combined with particle distribution trajectories can better solve the problem of reasonable equipment layout and no eddy currents at the lowest airflow speed, so as to avoid the re-involvement of pollutants. However, the application of this method is still difficult and has not been popularized yet.